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But 23% is still a meaningful step up from what semaglutide (Wegovy) achieves on its own, where the average tends to land around 14 to 15%

GHK-Cu occupies a different regulatory space in Canada

In biochemical and preclinical models, the peptide appears to regulate endothelial activity, cell migration, and cytoskeletal organization through interactions with kinase signaling cascades and nitric oxide related mechanisms

Efficacy of High-Dose Liraglutide as an Adjunct for Weight Loss in Patients with Prior Bariatric Surgery

The GHK sequence itself is naturally present in collagen and SPARC (Secreted Protein Acidic and Rich in Cysteine) protein, suggesting it functions as an emergency response molecule released during tissue injury through protein breakdown

This reinforces the need for carefully titrated regimens, especially in clinical settings where circadian timing (chronopharmacology) may dictate efficacy